Science Thu, 14 Nov 2024 23:10:52 +0000

SPL13 controls a root apical meristem phase change by triggering oriented cell divisions | Science Oriented cell divisions are crucial for determining the overall morphology and size of plants, but what controls the onset and duration of this process remains largely unknown. Here, we identified a small molecule that activates root apical meristem (RAM)... A glutamine metabolic switch supports erythropoiesis | Science Metabolic requirements vary during development, and our understanding of how metabolic activity influences cell specialization is incomplete. Here, we describe a switch from glutamine catabolism to synthesis required for erythroid cell maturation. ... Chemical genetic approaches to dissect microbiota mechanisms in health and disease | Science Advances in genomics, proteomics, and metabolomics have revealed associations between specific microbiota species in health and disease. However, the precise mechanism(s) of action for many microbiota species and molecules have not been fully elucidated, ... A breakthrough cancer immunotherapy is now taking aim at autoimmune disease  CAR-T therapy is generating excitement for lupus, scleroderma, and other conditions as clinical trials expand News at a glance: Replication troubles, financial conflict disclosures, and a public health shake-up  The latest in science and policy The metaphors of artificial intelligence | Science A few months after ChatGPT was released, the neural network pioneer Terrence Sejnowski wrote about coming to grips with the shock of what large language models (LLMs) could do: “Something is beginning to happen that was not expected even a few years ... In Other Journals | Science Editors’ selections from the current scientific literature In Science Journals | Science Highlights from the Science family of journals To target, to escape, perchance to cure: Borrowing a page from cancer’s playbook, scientists learn to evade their own therapies | Science Borrowing a page from cancer’s playbook, scientists learn to evade their own therapies How to build a human: Piecing together the body’s cellular puzzle | Science Piecing together the body’s cellular puzzle Digging below the surface: Hidden risks for ground-nesting bees | Science Hidden risks for ground-nesting bees Gatekeepers of the brain: Identifying hidden mechanisms of type A GABA receptor signaling and assembly | Science Identifying hidden mechanisms of type A GABA receptor signaling and assembly Plastics treaty: Address building materials | Science The final planned negotiation session of the Global Plastics Treaty will take place from 25 November to 1 December in Busan, Republic of Korea (1). Negotiators hope to provide the treaty’s future signatories with internationally, legally binding obligations that can effectively mitigate plastic pollution. Most discussions so far have focused on the largest category of plastics: packaging and single-use products (2). However, effective strategies must also address the second-largest global plastic category: building and construction materials, which accounted for 17% of plastic use in 2019 (3). Without intervention, demands for plastic building materials are projected to nearly double by 2050 to 150 million metric tonnes, a quantity that would surpass the 2019 level of plastic packaging production (4). The Global Plastics Treaty must include commitments to reduce plastics used in construction. End illegal sand mining in China | Science China is the world’s largest producer and consumer of sand gravel and crushed rocks, with an annual consumption of 20 billion metric tons, accounting for nearly half of global consumption (1, 2). Sand mining activities alter riverbed and lakebed topography and disrupt aquatic habitats and river ecosystems (3). These environmental changes threaten the safety of downstream bridges, embankments, underwater structures, and flood prevention infrastructure (3). China’s Ministry of Water Resources has implemented regulations to curb sand mining, but companies continue to engage in mining activities, sometimes with the permission of local governments (4). China must take steps to streamline and enforce sand mining bans. Argentina’s unsustainable policies | Science HomeScienceVol. 386, No. 6723Argentina’s unsustainable policiesBack To Vol. 386, No. 6723 Full accessLetter Share on Argentina’s unsustainable policiesSofia Capasso [email protected] and Verónica CapassoAuthors Info & AffiliationsScience14 Nov 2024Vol 386, Issue 6723pp. 735-736DOI: 10.1126/science.adr8529 PREVIOUS ARTICLEA voyage to victoryPreviousNEXT ARTICLEEnd illegal sand mining in ChinaNext … A voyage to victory | Science Players help Darwin discover new species and develop scientific theories in a fast-paced board game Tomorrow’s trees | Science An ecologist probes the future of forests The disciplinary matrix of holobiont biology | Science Uniting life’s seen and unseen realms guides a conceptual advance in research Learning the language of DNA | Science A genomic foundation model broadly enables sequence modeling, prediction, and design The journey to a mechanical qubit | Science An acoustic resonator can be directly manipulated to store quantum information Heat up to catch carbon | Science A metal-organic framework is activated to capture carbon dioxide at high temperatures Advancing alternative methods to reduce animal testing | Science Emerging approaches show promise for regulatory use Science is neither red nor blue | Science Long before the 5 November US presidential election, I had become ever more concerned that science has fallen victim to the same political divisiveness tearing at the seams of American society. This is a tragedy because science is the best—arguably the ... Research advocates see ‘no good news’ in Trump’s economic, immigration agenda  Republican control of Congress will help him with agency appointments and policy shifts ‘More mortality, more illness’: Global health community braces for impact of U.S. election  Scientists worry Trump will leave WHO and make deep cuts in programs that aim to control diseases worldwide Russia postpones three major science projects  Trade sanctions and budget woes delay new x-ray sources and neutron beams Preprint on Alzheimer’s drug deaths ignites dispute among authors  Co-authors say preliminary data on lecanemab fatalities don’t support the paper’s claims Saved from the scrapyard, this famed ‘flipping ship’ gets a second shot at ocean research  U.K. firm plans to revamp FLIP before deploying it to study air-sea interactions and how sonar beams travel Time to take stock | Science The reelection of Donald Trump for a second, nonconsecutive term as US president—mirroring only Grover Cleveland’s 22nd and 24th presidencies after the Civil War—underscores a reality: Although his success stems partly from a willingness to tap into ... Trump won. Is NIH in for a major shake-up?  Congress might serve as a bulwark, but some changes may be coming