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Tumor-derived erythropoietin acts as an immunosuppressive switch in cancer immunity | Science Successful cancer immunotherapy requires a patient to mount an effective immune response against tumors; however, many cancers evade the body’s immune system. To investigate the basis for treatment failure, we examined spontaneous mouse models of ... Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States | Science Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected wild birds, ... Distinct adipose progenitor cells emerging with age drive active adipogenesis | Science Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat undergo extensive adipogenesis during middle age. Thus, ... A well-connected Earth: The science and conservation of organismal movement | Science Global biodiversity targets focus on landscape and seascape connectivity as a foundational component of biodiversity conservation, including networks of connected protected areas. Recent advances allow the measurement and prediction of organismal ... Vietnam War’s survivors shed light on the long-term tolls of military conflict  Researchers are working with people who lived through the war as teenagers to understand conflict’s long-term tolls In Vietnam, the health effects of Agent Orange remain uncertain 50 years later  Researchers struggle to document the long-term impact of massive herbicide spraying News at a glance: claimed exoplanet life signs, an advance in ultracold microscopy, and slashed funds for U.S. environmental research  The latest in science and policy Governance can’t be automated | Science On the corners of the Holborn viaduct in central London, there are four statues: Commerce, Agriculture, Fine Art, and Science. The figure representing Science looks like she should be in Ancient Greece, but she is incongruously holding a Victorian ... In Other Journals | Science Editors’ selections from the current scientific literature In Science Journals | Science Highlights from the Science family of journals Rallying for US science | Science HomeScienceVol. 388, No. 6745Rallying for US scienceBack To Vol. 388, No. 6745 Full accessLetterOutside the Tower Share on Rallying for US scienceItai YanaiAuthors Info & AffiliationsScience24 Apr 2025Vol 388, Issue 6745p. 371DOI: 10.1126/science.adx5622 PREVIOUS ARTICLEUS scientists must stand togetherPreviousNEXT ARTICLEIn Science JournalsNext NotificationsBookmark ContentsReferences and Notes… US scientists must stand together | Science US federal support for science is eroding (1), and the future of US scientific agencies and institutions is uncertain. Simultaneously, the Trump administration is scapegoating minority groups, including immigrants, trans people, people of color, and disabled people (2–4). In the face of this federal onslaught, scientists may feel uncertain about how to respond. Speaking up may feel risky or even futile, but the risk of backlash grows with each day that silence becomes the norm (5, 6). Now is the time for scientists to ask more of each other and demand more from our institutions. Science, not silence: Save US economic growth | Science HomeScienceVol. 388, No. 6745Science, not silence: Save US economic growthBack To Vol. 388, No. 6745 Full accessLetter Share on Science, not silence: Save US economic growthPhilip PhillipsAuthors Info & AffiliationsScience24 Apr 2025Vol 388, Issue 6745p. 370DOI: 10.1126/science.adx7500 PREVIOUS ARTICLEEditor’s notePreviousNEXT ARTICLEUS scientists must stand togetherNext NotificationsBookmark Co… Editor’s note | Science On 15 September 2022, Science published the Research Article “Structural basis for strychnine activation of human bitter taste receptor TAS2R46” by W. Xu et al. (1). On 22 November 2022, an Editorial Expression of Concern alerted readers to concerns regarding fig. S10D (1). The authors have now corrected the paper, and the Editorial Expression of Concern has been replaced by an Erratum (3). As described in the Erratum, the authors repeated bioluminescence energy transfer experiments that were the basis for figs. S9, C to F, and S10D. The new data did not provide strong functional support for the structure-based suggestion of precoupling between TAS2R46 and the G protein gustducin. In the corrected version of the Research Article, Xiaoling Cao is no longer an author; figs. S9, C to F, and S10D have been removed; and the conclusions on precoupling are weaker than in the original version. The editors remain confident in the key findings of the paper: the cryo–electron microscopy structures of human TAS2R46 complexed with chimeric mini–G protein gustducin, in both strychnine-bound and apo forms. Science of death | Science HomeScienceVol. 388, No. 6745Science of deathBack To Vol. 388, No. 6745 Full accessBooks et al.Podcast Share on Science of deathScience24 Apr 2025Vol 388, Issue 6745p. 369DOI: 10.1126/science.adx9075 PREVIOUS ARTICLEMissed connectionsPreviousNEXT ARTICLEEditor’s noteNext NotificationsBookmark ContentsInformation & AuthorsMetrics & CitationsView OptionsReferencesFiguresTablesMediaShare Related po… Missed connections | Science Early investigators struggled to link contagious diseases and their causative agents The variable nature of sex | Science An anthropologist shows why we should think beyond the binary Partisan disparities in the use of science in policy | Science Documents from Congress and think tanks reflect differences in how science is cited Reimagining silicone’s life cycle | Science Synchronized catalysis breaks down silicone polymer waste into starting monomers The cellular basis for middle-age spread | Science Age-specific adipocyte progenitors drive visceral adipose tissue expansion in middle age Epo-calypse now | Science Blocking erythropoietin receptor signaling in macrophages promotes antitumor immunity Integrating exposomics into biomedicine | Science Assessing a full range of environmental exposures will improve human health Did the United States commit ‘ecocide’? | Science HomeScienceVol. 388, No. 6745Did the United States commit ‘ecocide’?Back To Vol. 388, No. 6745 Full accessFeature Share on Did the United States commit ‘ecocide’?Dennis NormileAuthors Info & AffiliationsScience24 Apr 2025Vol 388, Issue 6745p. 353DOI: 10.1126/science.ady4159 PREVIOUS ARTICLEThe fog of warPreviousNEXT ARTICLEA 50-year shadowNext NotificationsBookmark ContentsInformation & AuthorsM… Convergence and consensus | Science In these days of political instability, geopolitical tensions, and social discontent around the world, there are continued threats to the principles, conduct, and findings of science. This assault on science has been fueled by flooding the public with ... Massive pea study solves last genetic riddles of famed friar  DNA sequencing reveals basis of traits studied by Gregor Mendel—and gives breeders new ways to improve the crop In killing grants, NSF appears to follow Ted Cruz’s blueprint  Senator’s report targeted up to $2 billion for diversity, climate change, and misinformation research NIH freezes funds to Harvard and four other universities, but can’t tell them  Move follows broader White House attack on Harvard funding and stop-work orders to contractors Chinese star catalog is the world’s oldest, astronomers claim  Novel computer analysis of records ascribed to legendary Chinese astrologer dates them to nearly 2400 years ago Global pandemic treaty finalized, without U.S., in ‘a victory for multilateralism’  Three years in the making, the accord aims to increase equity and avoid errors of the COVID-19 pandemic For economists, Trump’s trade war offers a rare opportunity to study tariffs  Chance to test trade theories might be “the only silver lining” in chaotic policies, one says